The film premiered on March 2, 2012 - Dr. Seuss' 108th birthday.
When playing board games with the family, Grammy Norma makes the word "Lorax" with the scrabble balls she has.
The characters of Ted and Audrey are named after Dr. Seuss (whose real name was Theodor Seuss Geisel) and his second wife, Audrey Geisel.
This is the first film to feature Universal's 100th Anniversary logo.
This was the 11th biggest grossing film of 2012.
Unlike the original book, the Once-ler is shown fully in the story as a human. According to Chris Meledandri, "The minute you make the Once-ler a monster, you allow the audience to interpret that the problem is caused by somebody who is different from me, and it ceases to be a story that is about all of us. Then it's a story about, 'Oh I see, the person who led us into the predicament is not a person. It's somebody very, very different.' And so it takes you off the hook." 
While Ted gathers the items needed to see the Once-ler. A minion figurine can be briefly seen.
Also, Ted's sneakers brand are "Gru's Shoes", with a minion as the logo.
This is the first Illumination Entertainment film to use profanity; O'Hare once mutters "damn" during the chase scene near the end. This was the only noted reason for the film's PG rating from the MPAA. However, if there was no profanity being used in the film, then it would have been rated G.