Unlike other items, it does not spawn during runs. However, an icon resembling a chemical bottle with purple liquid can be seen at the top left of the screen. When this is tapped, the player's Minion becomes an Evil Minion. They can then run around frantically destroying anything for a few seconds. While running, all items turn into PX-41 Serum Flasks, which increase the time to run by 3 seconds per Flask.
Also, each Despicable Action caused by destroying obstacles while using the PX4 rapidly increases their Despicable Multiplier. Therefore, if the PX41 is used in an area where lots of obstacles spawn at one time, the player will rapidly increase their own Despicable Multiplier to levels such as 6 or higher. This can come in handy when trying to collect fruits for Despicable Action quests in the Jelly Lab, along with the Freeze Ray and Mega Minion.
This destructive item may seem awesom, but there's absolutely no chance to abuse them. After using the PX-41, players will have to wait hours for it to be able to be used again. It also offers no protection from falling into a void. Also, much like the Minion Launcher, it can only be upgraded using tokens. The PX-41, along with the Freeze Ray, Banana Splitter, Banana Vacuum, Minion Shield and Minion Launcher is one of the few items that does not allow the player to tilt the screen in order to use.
- With the first row of upgrades the duration of the PX-41 can be increased to a total of 30 seconds.
- The second row of upgrades adds a Despicable Score Multiplier bonus of 1x per upgrade level after each use.
- The icon used to be at the bottom left corner of the screen; due to various complaints about tapping the PX-41's icon accidentally in Minion Rush and activating it, it is moved to the current place in later updates.
- This is the only manual power-up in-game, also the only one that does not normally spawn during runs, and the only one with a CD after usage.