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Dr. Nefario

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Don't you think, that there's more to our future than jelly?
— Dr. Nefario
Dr. Nefario



Gender Male
Eye color Unknown
Hair color Gray

Gru's gadget man


Felonius Gru
Margo Gru
Edith Gru
Agnes Gru
Lucy Wilde
El Macho (formerly)


Vector Perkins
El Macho
Evil Minions


Despicable Me
Despicable Me 2

Voiced by

Russell Brand

Dr. Nefario is Gru's gadgeteer residing in his underground lair and laboratories, who builds and designs most of Gru's machines. Gru and Dr. Nefario seem to have been trying to shock the world with "The True Crime of the Century" for several years. Although Nefario has doubts about Gru's plans due to lack of funds, and his new found love for his adopted daughters, he still considers him to be "one of the greats" in the supervillain world. Dr. Nefario also has terrible hearing, mistaking Gru's orders for "dart gun" and "cookie robots" as "fart gun" and "boogie robots", respectively. He is one of the tritagonists in Despicable Me and a former supporting antagonist in Despicable Me 2.


Dr. Nefario dresses like a stereotypical mad scientist. He is generally elderly, mildly overweight, and apparently has trouble hearing, which frequently gives him trouble with initial consonants. He is never seen without his labcoat, gloves, and trademark goggles. He wears either pants or pajama bottoms with a plaid pattern. His hair, what little there is of it, is longish and faintly unruly.


Dr. Nefario is Gru's closest and most loyal friend coming to his rescue when Gru fell off Vectors ship and helping him rescue Agnes, Edith, and Margo even though he didn't seem to like them much. Nefario thought the three girls are a distraction and sent them back to Miss Hattie when he felt that Gru is not putting enough effort into their plot to steal the moon. He respected Gru and told him that he thought he is one of the best villains in the world, but nevertheless had some doubts about Gru's ability to steal the moon due to lack of funds and his love for his adopted daughters. Nefario is a scientific genius and invented "the Nefario principle" when he explained that the larger an object or person's mass is, the quicker the effects of the Shrink Ray that they stole wear off. He is also quite eccentric with rather bad hearing due to his age but although he seemed a little odd at times he did not seem to be going senile. In time, he came to accept the girls being a prominent facet of Gru's life.

Dr Nefario has had a hard time adapting to Gru's life as a regular person, missing the old days of supervilliany and feeling somewhat unproductive now that they are no longer committing crimes. Dr. Nefario feels that he needs new employment because he didn't like making the horrible jelly and jams for Gru, and didn't like being good (the Anti-Villain League supplied weaponry and equipment when he joined AFTER this scene) and so leaves Gru and works  for his arch enemy, Eduardo Perez. Dr. Nefario then abducts the Minions and mutates them for El Macho's take over the world scheme. Dr. Nefario then changes sides again, and warns Gru about Eduardo kidnapping Lucy Wilde. In this sense, Dr. Nefario can be seen as an anti-hero, as he's willing to change sides but, nevertheless, is still loyal to Gru and his family.

His accent suggests a British family lineage. Nefario seems to enjoy disco dancing and is even briefly shown doing so alongside Marlena Gru, and in the Boogie Robot scene.


Despicable Me

When Gru returns home, Dr. Nefario informs the supervillain that someone else stole the Pyramid of Giza. Dr. Nefario attends to the plan of stealing the Moon. Dr. Nefario makes Cookie Robots for Gru's plan of stealing the Shrink Ray from Vector.  Gru is later distracted by MargoEdith, and Agnes and Dr. Nefario is angry about him. 

During the making of the rocket, Gru got more distracted that Dr. Nefario called Ms. Hattie to pick up the girls. Gru continues the plan and Nefario notices that the effect of the Shrink Ray will loose its effect. Dr. Nefario warns Gru and he calls it the Nefario Principle

At the end, Dr. Nefario video tapes the girls' dance. Later, he dances with Gru's mother.

Despicable Me 2

At the beginning of the film, Dr. Nefario makes a jam that has a lot of flavors into one flavor, but it turns out to be very bad tasting. Only Gru and two of the Minions tasted it and they did not like it (John just threw it and all the Minions are running for their lives). Dr. Nefario informs Gru that he misses being evil and that he has a new work. Later as a farewell for Dr. Nefario, the Minions do a 21 Fart Guns salute, but Dr. Nefario counted 22 (A minion farted). When the 21 Fart Guns salute ended, Dr. Nefario left slowly to his new life.

Later that same night, Dr. Nefario goes back to Gru's house. You can see only his shadow, not his body, but it is similar to Dr. Nefario, and he rings the doorbell. Phil later attends and greets Dr. Nefario, but Dr. Nefario just kidnaps him and leaves the house without closing the door.

When the Cinco de Mayo party is about to start at El Macho's place. Now that he worked for El Macho, he has some of the Minions trapped in a fake Paradise that he made and two by two, he injected the PX-41 serum to the Minions which mutated them into a Evil Minion

When Gru enters El Macho's secret lair and that he discovers that Eduardo Perez is really El Macho, Dr. Nefario appears and Gru is surprised that this (the job with El Macho) is his new job. Then Dr. Nefario and El Macho explain their plan and then El Macho asks if he wants to join in the group. Then Dr. Nefario opens a popper that threw confetti). Gru disappears and El Macho has a bad feeling that Gru is not on his side, so he releases Kevin—who is currently an Evil Minion).

Later when Eduardo discovers that Lucy Wilde and Gru worked for the AVL (The Anti-Villain League) and takes Lucy with him to his lab as a prisoner, Dr. Nefario is the only one who witnessed it. 

Dr. Nefario later calls Gru telling El Macho already knows that him and Lucy work for the AVL and that he had captured Gru's partner. Later El Macho looks for Dr. Nefario, so he cuts the call.

When MargoEdithAgnes, and the remaining Minions are attacked by Kevin, who is mutated into a Evil Minion, is injected an antidote by Dr. Nefario himself. He introduces the antidote to the girls, which worked well, and named it PX-41 Antidote. He later spread the antidote to the bad tasting jam that he made.

He, the girls, and the remaining Minions went to El Macho's lair and normalized the Evil Minions into Minions. He knocks out El Macho—who is mutated—with a Fart Gun.


Dr. Nefario showing his new Freeze Ray to his future partner, Felonius Gru.

In the ending, Dr. Nefario appears in the wedding as a guest, dances with Gru's mother while the Minions are singing the Y.M.C.A song, and appears in the family picture.


Dr. Nefario makes a small cameo as a young man, he is seen at Villain-Con showing off the Freeze Ray and accidentally freezes his own hand by mistake.


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  • Dr. Nefario shares a voice actor with E.B. from Illumination Entertainment's Hop. They were both voiced by Russell Brand.
  • Near the end of Despicable Me 2, where Dr. Nefario finally knock out a mutated El-Macho with a fart gun and then posed for a picture is a homage to the movie King Kong where after King Kong fell to his death from the Empire State Building, two soldiers made almost the exact same pose for the camera.
    • King Kong is also owned by Universal, the owner of the Despicable Me movies.


Felonius GruLucy WildeMargoEdithAgnesMinions (KevinStuartBob) • Dr. Nefario
VectorMr. PerkinsEduardoEvil MinionsPollitoJewel ThiefScarlet OverkillHerb Overkill
Other characters
AntonioCarnival BarkerKyleSilas RamsbottomMiss HattieMarlena GruAnchormanFloydFredJillianJustinJustin's FatherJustin's MotherPennyRobert GruShannonNatalieThe Social WorkerItalian WaiterSilas' ButlerMichelleJewel ThiefIce Cream VendorWalter NelsonMadge NelsonWalter Nelson Jr.Tina Nelson

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